Total synthesis of thiostrepton, Part 2: Construction of the quinaldic acid macrocycle and final stages of the synthesis

被引：73

作者：

Nicolaou, KC

Zak, M

Safina, BS

Lee, SH

Estrada, AA

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[3] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 38期

关键词：

antibiotics; natural products; peptide coupling; protecting groups; total synthesis;

D O I：

10.1002/anie.200461341

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The flagship of the thiopeptide class of antibiotics, thiostrepton (see formula), was synthesized by fusion of the quinaldic acid moiety onto the dehydropiperidine-thiazoline macrocycle (see above) followed by demasking of its sensitive functionalities.

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页码：5092 / 5097

页数：6

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