Distinct dynamics of HISTONE3 variants between the two fertilization products in plants

被引：218

作者：

Ingouff, Mathieu

Hamamura, Yuki

GourgueS, Mathieu

Higashiyama, Tetsuya

Berger, Frederic

机构：

[1] Natl Univ Singapore, Temasek Life Sci Lab, Chromatin & Reprod Grp, Singapore 117604, Singapore

[2] Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Tokyo 1130033, Japan

[3] UMR Interact Plantes Mircoorganismes & Sante Vege, F-06903 Sophia Antipolis, France

[4] Nagoya Univ, Grad Sch Sci, Div Biol Sci, Chikusa Ku, Nagoya, Aichi 4648602, Japan

来源：

CURRENT BIOLOGY | 2007年 / 17卷 / 12期

关键词：

DEVBIO;

D O I：

10.1016/j.cub.2007.05.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sexual reproduction involves epigenetic reprogramming [1] comprising DNA methylation [2] and histone modifications [3-6]. In addition, dynamics of HISTONE3 (H3) variant H3.3 upon fertilization are conserved in animals, suggesting an essential role [7-9]. In contrast to H3, H3.3 marks actively transcribed regions of the genome and can be deposited in a replication-independent manner [10, 11]. Although H3 variants are conserved in plants, their dynamics during fertilization have remained unexplored. We overcame technical limitations to live imaging of the fertilization process in Arabidopsis thaliana and studied dynamics of the male-gamete-specific H3.3 [12] and the centromeric Histone Three Related 12 (HTR12) [13]. The double-fertilization process in plants produces the zygote and the embryo-nourishing endosperm [14]. We show that the zygote is characterized by replication-independent removal of paternal H3.3 and homogeneous incorporation of parental chromatin complements. In the endosperm, the paternal H3.3 is passively diluted by replication while the paternal chromatin remains segregated apart from the maternal chromatin (gonomery). Hence epigenetic regulations distinguish the two products of fertilization in plants. H3.3-replication-independent dynamics and gonomery also mark the first zygotic divisions in animal species [5, 15]. We thus propose the convergent selection of parental epigenetic imbalance involving H3 variants in sexually reproducing organisms.

引用

页码：1032 / 1037

页数：6

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