Preclinical Alzheimer disease - Neuropsychological test performance 1.5 to 8 years prior to onset

被引:128
作者
Saxton, J
Lopez, OL
Ratcliff, G
Dulberg, C
Fried, LP
Carlson, MC
Newman, AB
Kuller, L
机构
[1] Univ Pittsburgh, Pittsburgh, PA 15213 USA
[2] HealthSouth Harmarville Rehabil Hosp, Pittsburgh, PA USA
[3] Univ Washington, Seattle, WA 98195 USA
[4] Johns Hopkins Univ, Baltimore, MD USA
关键词
D O I
10.1212/01.WNL.0000147470.58328.50
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: To determine if individuals ultimately diagnosed with Alzheimer disease ( AD) exhibited evidence of cognitive impairment on neuropsychological tests administered between 1.5 years and 8.1 years before dementia onset. Methods: A total of 693 community-dwelling individuals, part of the Cardiovascular Health Study, completed a neuropsychological test battery in 1991/92. Subjects were followed annually over the next 8 years (median follow-up = 7.4 years). Seventy-two individuals were ultimately diagnosed with AD (median follow-up = 4.5 years): 24 with AD onset 1.5 to 3.4 years after baseline neuropsychological testing, 20 with AD onset 3.5 to 5.0 years after testing, and 28 with onset 5.1 to 8.1 years after testing. A total of 621 individuals remained nondemented throughout the 8 years of follow-up ( median follow-up = 7.5 years). Results: Subjects ultimately diagnosed with AD had poorer scores on baseline neuropsychological measures than subjects who remained nondemented. Although individuals closest to AD onset (i.e., 1.5 to 3.4 years) performed the most poorly, cognitive impairment was detected in individuals who did not develop AD until 5 to 8 years later. Conclusions: Cognitive changes can be detected well before onset of Alzheimer disease.
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页码:2341 / 2347
页数:7
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