A case of interleukin-12 receptor β-1 deficiency with recurrent leishmaniasis

被引：33

作者：

Sanal, Ozden ^{[1
]}

Turkkani, Gulten

Gumruk, Fatma

Yel, Leman

Secmeer, Gulten

Tezcan, Ilhan

Kara, Ates

Ersoy, Fugen

机构：

[1] Hacettepe Univ, Childrens Hosp, Div Immunol, TR-06100 Ankara, Turkey

[2] Hacettepe Univ, Childrens Hosp, Div Hematol, TR-06100 Ankara, Turkey

[3] Hacettepe Univ, Childrens Hosp, Div Infect Dis, TR-06100 Ankara, Turkey

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2007年 / 26卷 / 04期

关键词：

mendelian susceptibility to mycobacterial disease; interleukin-12 receptor beta-1 deficiency; leishmaniasis; salmonella infection;

D O I：

10.1097/01.inf.0000258696.64507.0f

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-12 receptor beta-1 (IL-12R beta 1) defect is generally associated with selective susceptibility to weakly pathogenic mycobacteria and Salmonella species. Patients rarely experience infections caused by other organisms. We report a 5-year-old patient with IL-12R beta 1 deficiency who developed recurrent visceral leishmaniasis 6 months apart. The patient responded to lyposomal amphotericin B treatment reasonably well.

引用

页码：366 / 368

页数：3

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