The molecular basis of keloid and hypertrophic scar formation

被引:359
作者
Tuan, TL
Nichter, LS
机构
[1] Univ So Calif, Childrens Hosp Los Angeles, Sch Med, Dept Surg, Los Angeles, CA 90027 USA
[2] Univ So Calif, Sch Med, Dept Surg,Inst Plast Surg, Div Plast & Reconstruct Surg,PLASTICOS, Orange, CA 92668 USA
来源
MOLECULAR MEDICINE TODAY | 1998年 / 4卷 / 01期
关键词
D O I
10.1016/S1357-4310(97)80541-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Excess scar formation secondary to traumatic or surgical injuries can have devastating consequences, ranging from body disfigurement to organ dysfunction, Hypertrophic scars and keloids are skin fibrotic conditions that can be caused by minor insults to skin, such as acne or ear piercing, or by severe injuries such as burns, Differences between keloids, hypertrophic scars and normal scars include distinct scar appearance, histologic morphology and cellular function in response to growth factors. Recent advances in our understanding of the wound healing process reveal possible causes for hypertrophic scars and keloids, This information might assist in the development of efficacious treatment for hypertrophic scar and keloid formation.
引用
收藏
页码:19 / 24
页数:6
相关论文
共 33 条
[1]  
[Anonymous], 2014, SCI TRANSL MED, DOI DOI 10.1126/scitranslmed.3009337
[2]  
Appleton I, 1996, AM J PATHOL, V149, P1441
[3]   KELOID FIBROBLASTS EXHIBIT AN ALTERED RESPONSE TO TGF-BETA [J].
BABU, M ;
DIEGELMANN, R ;
OLIVER, N .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1992, 99 (05) :650-655
[4]   KELOIDS [J].
BERMAN, B ;
BIELEY, HC .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1995, 33 (01) :117-123
[5]   The effect of TGF-beta on keloid fibroblast proliferation and collagen synthesis [J].
Bettinger, DA ;
Yager, DR ;
Diegelmann, RF ;
Cohen, IK .
PLASTIC AND RECONSTRUCTIVE SURGERY, 1996, 98 (05) :827-833
[6]   NATURAL INHIBITOR OF TRANSFORMING GROWTH-FACTOR-BETA PROTECTS AGAINST SCARRING IN EXPERIMENTAL KIDNEY-DISEASE [J].
BORDER, WA ;
NOBLE, NA ;
YAMAMOTO, T ;
HARPER, JR ;
YAMAGUCHI, Y ;
PIERSCHBACHER, MD ;
RUOSLAHTI, E .
NATURE, 1992, 360 (6402) :361-364
[7]   Keloid excision and recurrence prophylaxis via intradermal interferon-gamma injections: A pilot study [J].
Broker, BJ ;
Rosen, D ;
Amsberry, J ;
Schmidt, R ;
Sailor, L ;
Pribitkin, EA ;
Keane, WM .
LARYNGOSCOPE, 1996, 106 (12) :1497-1501
[8]  
BURGESS LPA, 1990, ARCH OTOLARYNGOL, V116, P798
[9]  
DECLERCK YA, 1993, MECH DRUG RESISTANCE, P121
[10]   Intracellular signalling: The Mad way to do it [J].
Derynck, R ;
Zhang, Y .
CURRENT BIOLOGY, 1996, 6 (10) :1226-1229