The callipyge locus:: evidence for the trans interaction of reciprocally imprinted genes

被引：120

作者：

Georges, M

Charlier, C

Cockett, N

机构：

[1] Univ Liege, Fac Vet Med, Dept Genet, B-4000 Liege, Belgium

[2] Utah State Univ, Coll Agr, Dept Anim Dairy & Vet Sci, Logan, UT 84322 USA

来源：

TRENDS IN GENETICS | 2003年 / 19卷 / 05期

关键词：

D O I：

10.1016/S0168-9525(03)00082-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The callipyge phenotype in sheep is an inherited muscular hypertrophy that affects only heterozygous individuals who receive the CLPG mutation from their father. The CLPG mutation is a single nucleotide substitution in what is probably a long-range control element (LRCE) within the DLK1-GTL2 imprinted domain. Recent results suggest that the unique mode of inheritance of callipyge, referred to as polar overdominance, results from the combination of the cis-effect of the CLPG mutation on the expression levels of genes in the DLK1-GTL2 imprinted domain, and the trans interaction between the products of reciprocally imprinted genes.

引用

页码：248 / 252

页数：5

共 41 条

[1] [Anonymous], 1989, MOBILE DNA-UK
[2] Breakpoint mapping positions the callipyge gene within a 450-kilobase chromosome segment containing the DLK1 and GTL2 genes
Berghmans, S
Segers, K
Shay, T
Georges, M
Cockett, N
Charlier, C
[J]. MAMMALIAN GENOME, 2001, 12 (02) : 183 - 185
[3] Identification of tandemly-repeated C/D snoRNA genes at the imprinted human 14q32 domain reminiscent of those at the Prader-Willi/Angelman syndrome region
Cavaillé, J
Seitz, H
Paulsen, M
Ferguson-Smith, AC
Bachellerie, JP
[J]. HUMAN MOLECULAR GENETICS, 2002, 11 (13) : 1527 - 1538
[4] The callipyge mutation enhances the expression of coregulated imprinted genes in cis without affecting their imprinting status
Charlier, C
Segers, K
Karim, L
Shay, T
Gyapay, G
Cockett, N
Georges, M
[J]. NATURE GENETICS, 2001, 27 (04) : 367 - 369
[5] Human-ovine comparative sequencing of a 250-kb imprinted domain encompassing the callipyge (clpg) locus and identification of six imprinted transcripts:: DLK1, DAT, GTL2, PEG11, antiPEG11, and MEG8
Charlier, C
Segers, K
Wagenaar, D
Karim, L
Berghams, S
Jaillon, O
Shay, T
Weissenbach, J
Cockett, N
Gyapay, G
Georges, M
[J]. GENOME RESEARCH, 2001, 11 (05) : 850 - 862
[6] Polar overdominance at the Ovine callipyge locus
Cockett, NE
Jackson, SP
Shay, TL
Farnir, F
Berghmans, S
Snowder, GD
Nielsen, DM
Georges, M
[J]. SCIENCE, 1996, 273 (5272) : 236 - 238
[7] Analysis of the sheep genome
Cockett, NE
Shay, TL
Smit, M
[J]. PHYSIOLOGICAL GENOMICS, 2001, 7 (02) : 69 - 78
[8] CHROMOSOMAL LOCALIZATION OF THE CALLIPYGE GENE IN SHEEP (OVIS-ARIES) USING BOVINE DNA MARKERS
COCKETT, NE
JACKSON, SP
SHAY, TL
NIELSEN, D
MOORE, SS
STEELE, MR
BARENDSE, W
GREEN, RD
GEORGES, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (08) : 3019 - 3023
[9] Imprinting at the mouse Ins2 locus:: Evidence for cis- and trans-allelic interactions
Duvillié, B
Bucchini, D
Tang, TW
Jami, J
Pàldi, A
[J]. GENOMICS, 1998, 47 (01) : 52 - 57
[10] Comparative mapping of the ovine clpg locus
Fahrenkrug, SC
Freking, BA
Rexroad, CE
Leymaster, KA
Kappes, SM
Smith, TPL
[J]. MAMMALIAN GENOME, 2000, 11 (10) : 871 - 876

← 1 2 3 4 5 →