Fetal and adult human CNS stem cells have similar molecular characteristics and developmental potential

被引：31

作者：

Palm, K ^{[1
]}

Salin-Nordström, T ^{[1
]}

Levesque, MF ^{[1
]}

Neuman, T ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med,CSMC Burns & Allen Res Inst, Dept Surg,Neurofunct Surg Ctr, Los Angeles, CA 90048 USA

来源：

MOLECULAR BRAIN RESEARCH | 2000年 / 78卷 / 1-2期

关键词：

human neural stem cells; neurospheres; transcriptional regulators;

D O I：

10.1016/S0169-328X(00)00075-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The mammalian central nervous system (CNS) contains multipotent stem cells that develop into neurons, astrocytes and oligodendrocytes. Our current data show that fetal and adult human CNS stem cell isolates display similar proliferation kinetics, differentiate into three major cell types of the nervous system and express similar sets of regulatory genes. However, each individual CNS stem cell isolate could be distinguished by its specific gene expression and developmental potential. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：192 / 195

页数：4

共 27 条

[1] Regional incorporation and site-specific differentiation of striatal precursors transplanted to the embryonic forebrain ventricle [J].