Effect of selenium and vitamin E supplements on tissue lipids, peroxides, and fatty acid distribution in experimental diabetes

被引:41
作者
Douillet, C
Bost, M
Accominotti, M
Borson-Chazot, F
Ciavatti, M
机构
[1] INSERM U331, F-69375 Bron, France
[2] UNESCO, Trace Element Inst, F-69007 Lyon, France
[3] Hop Edouard Herriot, Dept Biochem Pharmacol, F-69008 Lyon, France
[4] Univ Claude Bernard, Dept Endocrinol Antiquaille, F-69008 Lyon, France
关键词
D O I
10.1007/s11745-998-0220-z
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The protective role of selenium (Se), given as a Se-rich yeast, selenomethionine or selenomethionine + vitamin E supplement, toward changes in lipid, peroxide, and fatty acid distribution in tissues of streptozotocin-induced diabetic rats, was investigated, after 24 wk of disease. Diabetes increased liver thiobarbituric acid-reactive substances and conjugated dienes; Se supplement completely corrected these changes. In kidney, as in heart, the peroxide levels were not significantly changed by diabetes. In diabetic rat liver, a significant drop in triglycerides and phospholipids (P < 0.05) was observed; this was modulated by Se + vitamin E supplementation. Se + vitamin E supplementation also inhibited the decrease in 18:2n-6 and the increase in 22:6n-3 observed in liver of diabetic rats, changes which reflect altered glycemic control. In kidney, heart, and aorta, diabetes produced some changes in lipid content and fatty acid distribution, especially an increase in heart triglycerides which was also corrected by the Se supplement. Se supplementation to diabetic rats also increased 18:0 ether-linked alcohol, 20:4 n-6, and 22:5 n-3 in cardiac lipids. In aorta, Se + vitamin E significantly increased 20:5 n-3. These polyunsaturated fatty acids are precursors, in situ, of prostaglandin l(2) (PGl(2)) and PGl(3) which may protect against cardiovascular dysfunction. In kidney, conversely, Se decreased 20:4 n-6, the precursor of thromboxane A(2) Implicated in diabetic glomerular injury. Thus Se, and more efficiently Se + Vitamin E supplementation, in experimental diabetes could play a role in controlling oxidative status and altered lipid metabolism in liver, thereby maintaining favorable fatty acid distribution in the major tissues affected by diabetic complications.
引用
收藏
页码:393 / 399
页数:7
相关论文
共 37 条
[1]   ROLE OF OXIDATIVE STRESS IN DEVELOPMENT OF COMPLICATIONS IN DIABETES [J].
BAYNES, JW .
DIABETES, 1991, 40 (04) :405-412
[2]   PROTECTION BY VITAMIN-E, SELENIUM, AND BETA-CAROTENE AGAINST OXIDATIVE DAMAGE IN RAT-LIVER SLICES AND HOMOGENATE [J].
CHEN, H ;
PELLETT, LJ ;
ANDERSEN, HJ ;
TAPPEL, AL .
FREE RADICAL BIOLOGY AND MEDICINE, 1993, 14 (05) :473-482
[3]   THROMBOXANE IN THE PATHOGENESIS OF GLOMERULAR INJURY IN DIABETES [J].
CRAVEN, PA ;
MELHEM, MF ;
DERUBERTIS, FR .
KIDNEY INTERNATIONAL, 1992, 42 (04) :937-946
[4]   ALTERED FATTY-ACID COMPOSITION IN THE PLASMA, PLATELETS, AND AORTA OF THE STREPTOZOTOCIN-INDUCED DIABETIC RAT [J].
DANG, AQ ;
FAAS, FH ;
LEE, JA ;
CARTER, WJ .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1988, 37 (11) :1065-1072
[5]   PROSTACYCLIN IS MAJOR PROSTAGLANDIN RELEASED FROM ISOLATED PERFUSED RABBIT AND RAT-HEART [J].
DEDECKERE, EAM ;
NUGTEREN, DH ;
HOOR, FT .
NATURE, 1977, 268 (5616) :160-163
[6]  
Douillet C, 1996, P SOC EXP BIOL MED, V211, P323, DOI 10.3181/00379727-211-43976
[7]   In vitro and in vivo effects of selenium and selenium with vitamin E on platelet functions in diabetic rats relationship to platelet sorbitol and fatty acid distribution [J].
Douillet, C ;
Bost, M ;
Accominotti, M ;
BorsonChazot, F ;
Ciavatti, M .
BIOLOGICAL TRACE ELEMENT RESEARCH, 1996, 55 (03) :263-277
[8]   EFFECT OF VITAMIN-E TREATMENT ON TISSUE FATTY-ACIDS AND CHOLESTEROL CONTENT IN EXPERIMENTAL DIABETES [J].
DOUILLET, C ;
CIAVATTI, M .
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 1995, 6 (06) :319-326
[9]   HIGH DOSAGE VITAMIN-E EFFECT ON OXIDATIVE STATUS AND SERUM-LIPIDS DISTRIBUTION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS [J].
DOUILLET, C ;
CHANCERELLE, Y ;
CRUZ, C ;
MARONCLES, C ;
KERGONOU, JF ;
RENAUD, S ;
CIAVATTI, M .
BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY, 1993, 50 (03) :265-276
[10]   ALTERED FATTY-ACID DESATURATION AND MICROSOMAL FATTY-ACID COMPOSITION IN THE STREPTOZOTOCIN DIABETIC RAT [J].
FAAS, FH ;
CARTER, WJ .
LIPIDS, 1980, 15 (11) :953-961