Sustained release of silver from periodontal wafers for treatment of periodontitis

被引:38
作者
Bromberg, LE
Braman, VM
Rothstein, DM
Spacciapoli, P
O'Connor, SM
Nelson, EJ
Buxton, DK
Tonetti, MS
Friden, PM
机构
[1] Periodontix Inc, Watertown, MA 02472 USA
[2] UCL, Eastman Dent Inst & Hosp, Dept Periodontol, London WC1X 8LD, England
关键词
periodontal wafers; silver nitrate; antimicrobial agent; staining;
D O I
10.1016/S0168-3659(00)00233-9
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Periodontal wafers intended to treat the underlying infections in patients with periodontitis have been developed. The wafers consist of poly(lactic-co-glycolic acid) as a primary bioerodible polymeric component, poly(ethylene glycol) as a plasticizer and encapsulation aid, and silver nitrate as the antimicrobial agent. The wafers are capable of sustained in vitro release of bioactive silver for at least 4 weeks. The wafers exhibit silver release that follows erosion kinetics, confirming a bulk erosion/release mechanism. In clinical evaluation, sustained release of silver at bactericidal levels for at least 21 days is observed. Staining of hard and soft tissues due to the released silver is minimal and reversible. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:63 / 72
页数:10
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