Palliative and adjuvant regional chemotherapy in pancreatic cancer

To improve the dismal prognosis of patients (pts) with pancreatic cancer we treated 32 patients with non-resectable (UICC LII, 17 pts; UICC IC 15 pts-group 1) and 20 patients with resected (UICC I, 1 pt; UICC II, 3 pts; UICC III, 16 pts-group 2) pancreatic cancer with palliative (group I) and adjuvant post-operative (group II) coeliac axis intra-arterial cyclic infusions (CAI), CAI consisted of mitoxantrone 10 mg/m(2) on day 1, folinic acid 170 mg/m(2) and 5-FU 600 mg/m(2) during days 2-4, and cis-platinum 60 mg/m(2) on day 5 for up to 11 (group I) or six (group II) cycles, In a total of 211 cycles toxicities at the level of WHO III occurred in 0-6% and of WHO IV in 0%, The median survival times, compared with institutional historical controls (treated vs controls), were 12 vs 4.8 months in UICC III (P < 0.006) and 4 vs 2.9 months in UICC IV (P < 0.05) group I pts, and 21 vs 9.3 months in group II (P < 0.0003), Hepatic disease progression appeared to be suppressed with CAI, which also appears to be effective for palliative and adjuvant treatment in non-resectable and resected pancreatic cancer.