Computer analysis of the entire budding yeast genome for putative targets of the GCN4 transcription factor

被引：18

作者：

Schuldiner, O ^{[1
]}

Yanover, C ^{[1
]}

Benvenisty, N ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Inst Life Sci, Dept Genet, IL-91904 Jerusalem, Israel

来源：

CURRENT GENETICS | 1998年 / 33卷 / 01期

关键词：

GCN4; genome; S-cerevisiae; transcription factor;

D O I：

10.1007/s002940050303

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The completion of the yeast genome project enables an analysis of various phenomena for a whole eukaryotic genome. We aimed at characterizing a full spectrum of target genes for a transcription activator, and specifically characterized putative targets for GCN4 in the budding yeast. The results suggest that about 1 % of the genes are regulated by GCN4 and that these genes code for proteins involved in amino-acid and nucleotide metabolism. Our analysis proposes that, when enough data about the binding nature of a transcription factor exists, it is possible to identify its putative targets and also to try and assign a physiological role for this transcription factor.

引用

页码：16 / 20

页数：5

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