The leptin connection: Regulatory T cells and autoimmunity

被引:31
作者
Hasenkrug, Kim J. [1 ]
机构
[1] NIAID, NIH, Lab Persistent Viral Dis, Hamilton, MT 59840 USA
关键词
D O I
10.1016/j.immuni.2007.02.002
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Leptin is a cytokine-like hormone with proinflammatory properties linked to autoimmune diseases. In this issue of Immunity, De Rosa et al. (2007) elucidate an important new role for leptin in the anergy and hyporesponsiveness of regulatory T cells.
引用
收藏
页码:143 / 145
页数:3
相关论文
共 9 条
[1]   A key role of leptin in the control of regulatory T cell proliferation [J].
De Rosa, Veronica ;
Procaccini, Claudio ;
Cali, Gaetano ;
Pirozzi, Giusepe ;
Fontana, Silvia ;
Zappacosta, Serafino ;
La Cava, Antonio ;
Matarese, Giuseppe .
IMMUNITY, 2007, 26 (02) :241-255
[2]   The weight of leptin in immunity [J].
La Cava, A ;
Matarese, G .
NATURE REVIEWS IMMUNOLOGY, 2004, 4 (05) :371-379
[3]   Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression [J].
Lord, GM ;
Matarese, G ;
Howard, LK ;
Baker, RJ ;
Bloom, SR ;
Lechler, RI .
NATURE, 1998, 394 (6696) :897-901
[4]   Leptin increase in multiple sclerosis associates with reduced number of CD4+CD25+ regulatory T cells [J].
Matarese, G ;
Carrieri, PB ;
La Cava, A ;
Perna, F ;
Sanna, V ;
De Rosa, V ;
Aufiero, D ;
Fontana, S ;
Zappacosta, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (14) :5150-5155
[5]   Towards a pro-inflammatory and immunomodulatory emerging role of leptin [J].
Otero, M. ;
Lago, R. ;
Gomez, R. ;
Dieguez, C. ;
Lago, F. ;
Gomez-Reino, J. ;
Gualillo, O. .
RHEUMATOLOGY, 2006, 45 (08) :944-950
[6]   Indirect effects of leptin receptor deficiency on lymphocyte populations and immune response in db/db mice [J].
Palmer, Gaby ;
Aurrand-Lions, Michel ;
Contassot, Emmanuel ;
Talabot-Ayer, Dominique ;
Ducrest-Gay, Dominique ;
Vesin, Christian ;
Chobaz-Peclat, Veronique ;
Busso, Nathalie ;
Gabay, Cem .
JOURNAL OF IMMUNOLOGY, 2006, 177 (05) :2899-2907
[7]   Foxp3+CD25+CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease [J].
Sakaguchi, Shimon ;
Ono, Masahiro ;
Setoguchi, Ruka ;
Yagi, Haruhiko ;
Hori, Shohei ;
Fehervari, Zoltan ;
Shimizu, Jun ;
Takahashi, Takeshi ;
Nomura, Takashi .
IMMUNOLOGICAL REVIEWS, 2006, 212 :8-27
[8]   Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses [J].
Sanna, V ;
Di Giacomo, A ;
La Cava, A ;
Lechler, RI ;
Fontana, S ;
Zappacosta, S ;
Matarese, G .
JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (02) :241-250
[9]   Leptin levels in the acute stage of ulcerative colitis [J].
Tuzun, A ;
Uygun, A ;
Yesilova, Z ;
Ozel, AM ;
Erdil, A ;
Yaman, H ;
Bagci, S ;
Gulsen, M ;
Karaeren, N ;
Dagalp, K .
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2004, 19 (04) :429-432