Primary hyperoxaluria:: Simultaneous combined liver and kidney transplantation from a living related donor

被引:28
作者
Astarcioglu, I
Karademir, S [1 ]
Gülay, H
Bora, S
Astarcioglu, H
Kavukcu, S
Türkmen, M
Soylu, A
机构
[1] Dokuz Eylul Univ, Sch Med, Transplantat Unit, Dept Gen Surg, TR-35340 Izmir, Turkey
[2] Dokuz Eylul Univ, Sch Med, Dept Pediat Nephrol, TR-35340 Izmir, Turkey
关键词
D O I
10.1053/jlts.2003.50072
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Primary hyperoxaluria type 1 (PH1) is a rare inherited metabolic disorder in which deficiency of the liver enzyme AGT leads to renal failure and systemic oxalosis. Timely, combined cadaveric liver-kidney transplantation (LKT) is recommended for end-stage renal failure (ESRF) caused by PHI; however, the shortage of cadaveric organs has generated enthusiasm for living-related transplantation in years. Recently, successful sequential LKT from the same living donor has been reported in a child with PHI. We present a sister-to-brother simultaneous LKT in a pediatric patient who suffered from PHI with ESRF. Twelve months after transplantation, his daily urine oxalate excretion was decreased from 160 mg to 19.5 mg with normal liver and renal allograft functions. In addition to the well-known advantages of living organ transplantation, simultaneous LKT may facilitate early postoperative hemodynamic stability and may induce immunotolerance and allow for low-dose immunosuppression.
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页码:433 / 436
页数:4
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