Kinesins to the core: The role of microtubule-based motor proteins in building the mitotic spindle midzone

被引:22
作者
Hornick, Jessica E. [1 ,3 ]
Karanjeet, Kul [2 ]
Collins, Elizabeth S. [2 ,4 ]
Hinchcliffe, Edward H. [2 ]
机构
[1] Northwestern Univ, Sch Med, Dept Obstet & Gynecol, Chicago, IL 60611 USA
[2] Univ Minnesota, Cell Dynam Sect, Hormel Inst, Austin, MN 55912 USA
[3] Northwestern Univ, Sch Med, Robert H Lurie Canc Ctr, Chicago, IL 60611 USA
[4] Univ Massachusetts, Dept Biol, Amherst, MA 01003 USA
基金
美国国家卫生研究院;
关键词
Mitosis; Cytokinesis; Microtubule; Motor protein; Kinesin; CELL-CYCLE PROGRESSION; GAMMA-TUBULIN; CITRON KINASE; CLEAVAGE FURROW; AURORA-B; MEMBRANE TRAFFICKING; ANAPHASE SPINDLE; BUNDLING PROTEIN; EXCHANGE FACTOR; MIDBODY MATRIX;
D O I
10.1016/j.semcdb.2010.01.017
中图分类号
Q2 [细胞生物学];
学科分类号
071013 [干细胞生物学];
摘要
In mammalian cultured cells the initiation of cytokinesis is regulated - both temporally and spatially - by the overlapping, anti-parallel microtubules of the spindle midzone. This region recruits several key central spindle components: PRC-1, polo-like kinase 1 (Plk-1), the centralspindlin complex, and the chromosome passenger complex (CPC), which together serve to stabilize the microtubule overlap, and also to coordinate the assembly of the cortical actin/myosin cytoskeleton necessary to physically cleave the cell in two. The localization of these crucial elements to the spindle midzone requires members of the kinesin superfamily of microtubule-based motor proteins. Here we focus on reviewing the role played by a variety of kinesins in both building and operating the spindle midzone machinery during cytokinesis. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码:290 / 299
页数:10
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