Amelioration of CR-EAE with lisofylline:: effects on mRNA levels of IL-12 and IFN-γ in the CNS

被引：11

作者：

Du, CG

Cooper, JC

Klaus, SJ

Sriram, S

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Neurol,Multiple Sclerosis Res Ctr, Vanderbilt Stallworth Rehabil Hosp, Nashville, TN 37212 USA

[2] Cell Therapeut Inc, Seattle, WA 98119 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2000年 / 110卷 / 1-2期

关键词：

lisofylline; experimental allergic encephalomyelitis; IL-12; IFN-gamma;

D O I：

10.1016/S0165-5728(00)00348-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CR-EAE is a Th1-mediated inflammatory autoimmune demyelinating disease of the CNS and serves as a model of human multiple sclerosis. Our previous studies have shown the protective effect of orally administered lisofylline in the prevention of active and passively induced acute EAE. In our present studies we have examined the efficacy and mechanism of action of lisofylline on CR-EAE. Lisofylline decreased the number and severity of paralytic attacks in mice with relapsing EAE. The reduction of clinical disease correlated with decreased levels of mRNA levels of IFN-gamma but not of mRNA levels of IL-12. These studies suggest that lisofylline may be an effective therapeutic for established Th1 mediated autoimmune disease and that it acts by blocking IL-12R signaling and not IL-12 production in vivo. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：13 / 19

页数：7

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