The angiotensin converting enzyme (ACE)

被引：192

作者：

Coates, D ^{[1
]}

机构：

[1] Univ Leeds, Fac Biol Sci, Sch Biol, Leeds LS2 9JT, W Yorkshire, England

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2003年 / 35卷 / 06期

关键词：

angiotensin converting enzyme; renin-angiotensin system; evolution of ACE; comparative and functional genomics;

D O I：

10.1016/S1357-2725(02)00309-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Angiotensin converting enzyme 1, found widely throughout the animal kingdom, is an integral membrane bound protein whose active sites are directed to the extracellular spaces. Two isoforms are expressed in mammals, a single domain germinal isoform required for male fertility, and a double domain somatic isoform which has a key role in the renin-angiotensin system. Both somatic domains are active with different substrate affinities. Mouse knockout experiments, and comparative work with invertebrate homologues, suggest that the two domains have clearly distinct roles. The importance of therapies involving inhibition of angiotensin converting enzyme are undisputed, but our understanding of how and why these therapies work is now being informed by the tools of genomic and comparative biology. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：769 / 773

页数：5

共 17 条

[1] Functional conservation of the active sites of human and Drosophila angiotensin I-converting enzyme [J].

Coates, D ;

Isaac, RE ;

Cotton, J ;

Siviter, R ;

Williams, TA ;

Shirras, A ;

Corvol, P ;

Dive, V .

BIOCHEMISTRY, 2000, 39 (30) :8963-8969

[2] Mice lacking endothelial angiotensin-converting enzyme have a normal blood pressure [J].

Cole, J ;

Le Quach, D ;

Sundaram, K ;

Corvol, P ;

Capecchi, MR ;

Bernstein, KE .

CIRCULATION RESEARCH, 2002, 90 (01) :87-92

[3]

CORVOL P, 1995, METHOD ENZYMOL, V248, P283

[4] Angiotensin-converting enzyme 2 is an essential regulator of heart function [J].

Crackower, MA ;

Sarao, R ;

Oudit, GY ;

Yagil, C ;

Kozieradzki, I ;

Scanga, SE ;

Oliveira-dos-Santos, AJ ;

da Costa, J ;

Zhang, LY ;

Pei, Y ;

Scholey, J ;

Ferrario, CM ;

Manoukian, AS ;

Chappell, MC ;

Backx, PH ;

Yagil, Y ;

Penninger, JM .

NATURE, 2002, 417 (6891) :822-828

[5]

DANILOV S, 1994, J BIOL CHEM, V269, P26806

[6] Use of angiotensin-converting enzyme inhibitors in patients with diabetes and coronary artery disease [J].

Dell'Italia, LJ ;

Rocic, P ;

Lucchesi, PA .

CURRENT PROBLEMS IN CARDIOLOGY, 2002, 27 (01) :6-36

[7] RXP 407, a phosphinic peptide, is a potent inhibitor of angiotensin I converting enzyme able to differentiate between its two active sites [J].

Dive, V ;

Cotton, J ;

Yiotakis, A ;

Michaud, A ;

Vassiliou, S ;

Jiracek, J ;

Vazeux, G ;

Chauvet, MT ;

Cuniasse, P ;

Corvol, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (08) :4330-4335

[8]

Esther CR, 1996, LAB INVEST, V74, P953

[9] The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice [J].

Esther, CR ;

Marino, EM ;

Howard, TE ;

Machaud, A ;

Corvol, P ;

Capecchi, MR ;

Bernstein, KE .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (10) :2375-2385

[10] Toward a role for angiotensin-converting enzyme in insects [J].

Isaac, RE ;

Schoofs, L ;

Williams, TA ;

Corvol, P ;

Veelaert, D ;

Sajid, M ;

Coates, D .

TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY: FROM MOLECULAR TO INTEGRATIVE BIOLOGY, 1998, 839 :288-292

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