All wrapped up

被引：11

作者：

Choo, Y ^{[1
]}

Schwabe, JWR ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

来源：

NATURE STRUCTURAL BIOLOGY | 1998年 / 5卷 / 04期

关键词：

D O I：

10.1038/nsb0498-253

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

How is it possible that nine small repeated 'zinc finger' units (each spanning just 3 or 4 base pairs) can protect the whole 50 base pair binding site of TFIIIA and why should such a periodic protein structure give rise to such an asymmetric footprint on DNA? The crystal structure of the first six fingers of TFIIIA bound to 31 base pairs of DNA explains everything: not all zinc fingers act alike.

引用

收藏

页码：253 / 255

页数：3

相关论文

共 19 条

[1] Physical basis of a protein-DNA recognition code [J].

Choo, Y ;

Klug, A .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1997, 7 (01) :117-125

[2] SEQUENCE-SPECIFIC BINDING OF THE N-TERMINAL 3-FINGER FRAGMENT OF XENOPUS TRANSCRIPTION FACTOR-IIIA TO THE INTERNAL CONTROL REGION OF A 5S RNA GENE [J].

CHRISTENSEN, JH ;

HANSEN, PK ;

LILLELUND, O ;

THOGERSEN, HC .

FEBS LETTERS, 1991, 281 (1-2) :181-184

[3] MODE OF INTERACTION OF THE ZINC FINGER PROTEIN TFIIIA WITH A 5S RNA GENE OF XENOPUS [J].

CHURCHILL, MEA ;

TULLIUS, TD ;

KLUG, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (14) :5528-5532

[4] MOLECULAR-BASIS FOR SPECIFIC RECOGNITION OF BOTH RNA AND DNA BY A ZINC FINGER PROTEIN [J].

CLEMENS, KR ;

WOLF, V ;

MCBRYANT, SJ ;

ZHANG, PH ;

LIAO, XB ;

WRIGHT, PE ;

GOTTESFELD, JM .

SCIENCE, 1993, 260 (5107) :530-533

[5] RELATIVE CONTRIBUTIONS OF THE ZINC FINGERS OF TRANSCRIPTION FACTOR IIIA TO THE ENERGETICS OF DNA-BINDING [J].

CLEMENS, KR ;

ZHANG, PH ;

LIAO, XB ;

MCBRYANT, SJ ;

WRIGHT, PE ;

GOTTESFELD, JM .

JOURNAL OF MOLECULAR BIOLOGY, 1994, 244 (01) :23-35

[6] Zif268 protein-DNA complex refined at 1.6 angstrom: A model system for understanding zinc finger-DNA interactions [J].

ElrodErickson, M ;

Rould, MA ;

Nekludova, L ;

Pabo, CO .

STRUCTURE, 1996, 4 (10) :1171-1180

[7] A NEW APPROACH TO THE ANALYSIS OF DNASE I FOOTPRINTING DATA AND ITS APPLICATION TO THE TFIIIA/5S DNA COMPLEX [J].

FAIRALL, L ;

RHODES, D .

NUCLEIC ACIDS RESEARCH, 1992, 20 (18) :4727-4731

[8] THE CRYSTAL-STRUCTURE OF A 2 ZINC-FINGER PEPTIDE REVEALS AN EXTENSION TO THE RULES FOR ZINC-FINGER DNA RECOGNITION [J].

FAIRALL, L ;

SCHWABE, JWR ;

CHAPMAN, L ;

FINCH, JT ;

RHODES, D .

NATURE, 1993, 366 (6454) :483-487

[9] Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator [J].

Houbaviy, HB ;

Usheva, A ;

Shenk, T ;

Burley, SK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (24) :13577-13582

[10] Synergy between adjacent zinc fingers in sequence-specific DNA recognition [J].

Isalan, M ;

Choo, Y ;

Klug, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (11) :5617-5621