Role of the Gut Microbiome in the Pathogenesis of Obesity and Obesity-Related Metabolic Dysfunction

被引：331

作者：

Bouter, Kristien E. ^{[1
]}

van Raalte, Daniel H. ^{[2
,3
]}

Groen, Albert K. ^{[1
,4
]}

Nieuwdorp, Max ^{[1
,2
,3
,5
]}

机构：

[1] Univ Amsterdam, AMC, Dept Vasc Med, Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Med Ctr, Dept Internal Med, Diabet Ctr, Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Med Ctr, Inst Cardiovasc Res ICaR, Amsterdam, Netherlands

[4] Univ Groningen, Univ Med Ctr Groningen, Lab Metab Dis, Dept Pediat, Groningen, Netherlands

[5] Univ Gothenberg, Wallenberg Lab, Gothenburg, Sweden

来源：

GASTROENTEROLOGY | 2017年 / 152卷 / 07期

关键词：

Gut Microbiota; Obesity; Diabetes; Fecal Transplantation; INTESTINAL MICROBIOTA; FECAL MICROBIOTA; TRANSPLANTATION; DIET; INFLAMMATION; METAGENOME; EXPRESSION; BACTERIAL; BENEFITS; NUTRIENT;

D O I：

10.1053/j.gastro.2016.12.048

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

The potential role of intestinal microbiota in the etiology of various human diseases has attracted massive attention in the last decade. As such, the intestinal microbiota has been advanced as an important contributor in the development of obesity and obesity-related metabolic dysfunctions, amongst others. Experiments in animal models have produced evidence for a causal role of intestinal microbiota in the etiology of obesity and insulin resistance. However, with a few exceptions, such causal relation is lacking for humans and most publications merely report associations between intestinal microbial composition and metabolic disorders such as obesity and type 2 diabetes. Thus, the reciprocal relationship between the bacteria and these metabolic disorders remains a matter of debate. The main objective of this review is to critically assess the driving role of intestinal microbe composition in the etiology, prevention, and treatment of obesity and obesity-related metabolic dysfunction, including type 2 diabetes.

引用

页码：1671 / 1678

页数：8

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