miR-1/miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes

被引：230

作者：

Shan, Zhi-Xin ^{[1
]}

Lin, Qiu-Xiong ^{[1
]}

Deng, Chun-Yu ^{[1
]}

Zhu, Jie-Ning ^{[1
]}

Mai, Li-Ping ^{[1
]}

Liu, Ju-Li ^{[1
]}

Fu, Yong-Heng ^{[1
]}

Liu, Xiao-Ying ^{[1
]}

Li, Yang-Xin ^{[2
,3
]}

Zhang, You-Yi ^{[4
]}

Lin, Shu-Guang ^{[1
]}

Yu, Xi-Yong ^{[1
]}

机构：

[1] Guangdong Gen Hosp, Res Ctr, Guangdong Prov Cardiovasc Inst, Guangdong Acad Med Sci, Guangzhou 510080, Guangdong, Peoples R China

[2] St Lukes Episcopal Hosp, Texas Heart Inst, Houston, TX 77030 USA

[3] Univ Texas Hlth Sci Ctr, Houston, TX 77030 USA

[4] Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100083, Peoples R China

来源：

FEBS LETTERS | 2010年 / 584卷 / 16期

基金：

中国国家自然科学基金;

关键词：

miR-1; miR-206; Hsp60; High glucose; H9c2; cell; MUSCLE-SPECIFIC MICRORNA; CARDIAC-MUSCLE; GROWTH-FACTOR; I RECEPTOR; MITOCHONDRIA; HSP10; HEART; HEAT-SHOCK-PROTEIN-60; PROTECTION; PROTEINS;

D O I：

10.1016/j.febslet.2010.07.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hsp60 is an important component of defense mechanisms against diabetic myocardial injury; however, the cause of Hsp60 reduction in the diabetic myocardium remains unknown. After stimulation of cardiomyocytes with high glucose in vivo and in vitro, significant up-regulation of miR-1/miR-206 and post-transcriptional modulation of Hsp 60 were observed. Serum response factor (SRF) and the MEK1/2 pathway were involved in miR-1 and miR-206 expression in cardiomyocytes. miR-1 and miR-206 regulated Hsp60 expression post-transcriptionally and accelerated cardiomyocyte apoptosis through Hsp60. These results revealed that miR-1 and miR-206 regulate Hsp60 expression, contributing to high glucose-mediated apoptosis in cardiomyocytes. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：3592 / 3600

页数：9

共 37 条

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