Haematological effects of oral cobalamin preparations on patients with megaloblastic anaemia

被引:21
作者
Kondo, H [1 ]
机构
[1] Shimizu Kosei Hosp, Dept Med, Div Haematol & Oncol, Shimizu, Shizuoka 42401, Japan
关键词
cobalamin treatment; oral; cobalamin (vitamin B-12); megaloblastic anaemia; pernicious anaemia; postgastrectomy anaemia;
D O I
10.1159/000040839
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We investigated the haematological effects of a massive dose of oral cobalamin (vitamin B-12) On patients with cobalamin deficiency anaemia who had severe anaemia with a few neurological impairments and found that oral treatment was almost as effective as conventional injection therapy. The recovery of haematological indices with oral cobalamin preparations was slightly slower than with parenteral preparations, although the subjective symptoms disappeared soon after the start of therapy. The results of this study indicate that oral treatment keeps the cobalamin body stores satisfactorily filled and might be useful for older patients in whom injecting might be difficult.
引用
收藏
页码:200 / 205
页数:6
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