Chronic toxicity of Gynostemma pentaphyllum

被引：89

作者：

Attawish, A ^{[1
]}

Chivapat, S ^{[1
]}

Phadungpat, S ^{[1
]}

Bansiddhi, J ^{[1
]}

Techadamrongsin, Y ^{[1
]}

Mitrijit, O ^{[1
]}

Chaorai, B ^{[1
]}

Chavalittumrong, P ^{[1
]}

机构：

[1] Minist Publ Hlth, Dept Med Sci, Med Plant Res Inst, Muang 11000, Nonthaburi, Thailand

来源：

FITOTERAPIA | 2004年 / 75卷 / 06期

关键词：

Gynostemma pentaphyllum; chronic toxicity;

D O I：

10.1016/j.fitote.2004.04.010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The effect of water extract of Gynostemma pentaphyllum was evaluated on 6-month chronic toxicity in Wistar rats. Control group received orally 10 ml kg(-1) day(-1). The extract was orally given to the five treatment groups at the doses of 6, 30, 150, 750 and 750 mg kg(-1) day(-1) for 24 weeks. The last group served as the recovery group. The results showed that the extract did not produce any significant dose-related changes. Therefore, it is concluded that the extract of G. pentaphyllum at the given doses did not produce any significant toxic effect in rats during 6-month period of the treatment. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：539 / 551

页数：13

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