Colposcopic evaluation of a vaginal gel formulation of iota-carrageenan

被引:55
作者
Elias, CJ
Coggins, C
Alvarez, F
Brache, V
Fraser, IS
Lacarra, M
Lähteenmäki, P
Massai, R
Mishell, DR
Phillips, DM
Salvatierra, AM
机构
[1] Populat Council, New York, NY 10017 USA
[2] Populat Council, Bangkok, Thailand
[3] Asociac Dominicana Pro Bienestar Familia, Santo Domingo, Dominican Rep
[4] Sydney Ctr Reprod Hlth Res, Sydney, NSW, Australia
[5] Univ So Calif, Los Angeles, CA USA
[6] Family Federat Finland, Helsinki, Finland
[7] Inst Chileno Med Reprod, Santiago, Chile
关键词
microbicide; female-controlled barrier method; AIDS; spermicide; heterosexual transmission of human immunodeficiency virus; iota-carrageenan;
D O I
10.1016/S0010-7824(97)00176-5
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
There is an urgent need to develop safe, effective, and acceptable vaginal products for the prevention of sexually transmitted infections. Preliminary in vitro results suggest that vaginal formulations of sulfated polysaccharides, including iota-carrageenan, have the potential to block mucosal transmission of human immunodeficiency virus (HIV). Twenty-five women in Jive sites participated in Phase I trials to evaluate the safety of a formulation containing iota-carrageenan (PC 213). The results of this study indicate that a 5 mL 2% gel formulation of iota-carrageenan is not associated with significant irritation of the female reproductive tract when administered once daily in the absence of sexual intercourse. Given the small number of participants in this initial study, careful observation for potential irritation must also be included in larger studies of this and other vaginal formulations. (C) 1997 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:387 / 389
页数:3
相关论文
共 5 条
[1]  
Elias CJ, 1996, AIDS, V10, pS43
[2]  
*INT WORK GROUP VA, 1996, AIDS, P10
[3]   Sulfated polysaccharides inhibit lymphocyte-to-epithelial transmission of human immunodeficiency virus-1 [J].
PearcePratt, R ;
Phillips, DM .
BIOLOGY OF REPRODUCTION, 1996, 54 (01) :173-182
[4]  
STONE AB, 1994, AIDS S1, V8, P285
[5]  
*WHO, 1995, WHO MAN STAND COLP E