On the InterAktion between hexokinase and the mitochondrion

被引：25

作者：

Birnbaum, MJ ^{[1
]}

机构：

[1] Univ Penn, Howard Hughes Med Inst, Sch Med, Dept Med, Philadelphia, PA 19104 USA

来源：

DEVELOPMENTAL CELL | 2004年 / 7卷 / 06期

关键词：

D O I：

10.1016/j.devcel.2004.11.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The protein kinase Akt is now well recognized as a potent inhibitor of apoptosis. Work published by Majewski et al. in the December 31 issue of Molecular Cell indicates that a major pathway by which Akt suppresses cell death is by stimulating the translocation of hexokinase to the mitochondrion. Hexokinase, in turn, antagonizes the release of mitochondrial cytochrome C.

引用

页码：781 / 782

页数：2

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