CD8(+) T cells are activated during the early Th1 and Th2 immune responses in a murine Lyme disease model

被引：30

作者：

Dong, ZJ

Edelstein, MD

Glickstein, LJ

机构：

[1] TUFTS UNIV NEW ENGLAND MED CTR,DEPT MED,DIV RHEUMATOL IMMUNOL,BOSTON,MA 02111

[2] TUFTS UNIV,SCH MED,BOSTON,MA 02111

来源：

INFECTION AND IMMUNITY | 1997年 / 65卷 / 12期

关键词：

D O I：

10.1128/IAI.65.12.5334-5337.1997

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T-helper responses following Borrelia burgdorferi infection in mice determine susceptibility to Lyme arthritis. The ratio of interleukin 4-positive, CD4(+) to gamma interferon (IFN-gamma)-positive, CD4(+) T cells was significantly greater in infected BALB/cJ mice than in infected C3H/HeJ mice. Increased numbers of IFN-gamma-producing cells predicted greater arthritis severity, and CD8(+) T cells were the main source of IFN-gamma in both strains.

引用

收藏

页码：5334 / 5337

页数：4

相关论文

共 35 条

[1] INFECTIVITY OF BORRELIA-BURGDORFERI RELATIVE TO ROUTE OF INOCULATION AND GENOTYPE IN LABORATORY MICE [J].

BARTHOLD, SW .

JOURNAL OF INFECTIOUS DISEASES, 1991, 163 (02) :419-420

[2] LYME BORRELIOSIS IN SELECTED STRAINS AND AGES OF LABORATORY MICE [J].

BARTHOLD, SW ;

BECK, DS ;

HANSEN, GM ;

TERWILLIGER, GA ;

MOODY, KD .

JOURNAL OF INFECTIOUS DISEASES, 1990, 162 (01) :133-138

[3] CIRCUMVENTION OF OUTER SURFACE PROTEIN-A IMMUNITY BY HOST-ADAPTED BORRELIA-BURGDORFERI [J].

BARTHOLD, SW ;

FIKRIG, E ;

BOCKENSTEDT, LK ;

PERSING, DH .

INFECTION AND IMMUNITY, 1995, 63 (06) :2255-2261

[4] Induction of autoimmune diabetes by oral administration of autoantigen [J].

Blanas, E ;

Carbone, FR ;

Allison, J ;

Miller, JFAP ;

Heath, WR .

SCIENCE, 1996, 274 (5293) :1707-1709

[5]

Busch DH, 1996, J IMMUNOL, V157, P3534

[6] DIVERSE LYME-DISEASE SPIROCHETES BIND INTEGRIN ALPHA(IIB)BETA(3) ON HUMAN PLATELETS [J].

COBURN, J ;

BARTHOLD, SW ;

LEONG, JM .

INFECTION AND IMMUNITY, 1994, 62 (12) :5559-5567

[7] Exploitation of mammalian host cell functions by bacterial pathogens [J].

Finlay, BB ;

Cossart, P .

SCIENCE, 1997, 276 (5313) :718-725

[8] PRODUCTION OF INTERFERON-GAMMA, INTERLEUKIN-2, INTERLEUKIN-4, AND INTERLEUKIN-10 BY CD4+ LYMPHOCYTES INVIVO DURING HEALING AND PROGRESSIVE MURINE LEISHMANIASIS [J].

HEINZEL, FP ;

SADICK, MD ;

MUTHA, SS ;

LOCKSLEY, RM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (16) :7011-7015

[9]

KEANEMYERS A, 1995, J IMMUNOL, V154, P1770

[10]

KEANEMYERS A, 1995, J IMMUNOL, V155, P2020

← 1 2 3 4 →