Cloning and characterization of the mouse tob2 gene

被引：15

作者：

Ajima, R ^{[1
]}

Ikematsu, N ^{[1
]}

Ohsugi, M ^{[1
]}

Yoshida, Y ^{[1
]}

Yamamoto, T ^{[1
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Dept Oncol, Minato Ku, Tokyo 1088639, Japan

来源：

GENE | 2000年 / 253卷 / 02期

关键词：

intronless; mRNA expression; single locus; Tob/BTG1 anti-proliferative family;

D O I：

10.1016/S0378-1119(00)00270-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Human Tob2 is a member of the Tob/BTG1 anti-proliferative family of proteins. Here, we report the molecular cloning and characterization of the mouse tob2 gene. The tob2 gene contains an open reading frame of 345 amino acids with an 89% identity to its human counterparts. The coding region of mouse tob2 is not interrupted by introns. The tob2 transcript is 4.2 kb long, the size being similar to that of the human tob2 transcript, and detected ubiquitously in various tissues of adult mice. In addition, in situ hybridization shows that tob2 is ubiquitously expressed in embryo, the level of expression being especially high in skeletal muscle. Collectively, Tob2 is suggested to play roles both during embryogenesis and in adults. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：215 / 220

页数：6

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