Regioselective addition reaction of organolanthanide reagents to α,β-unsaturated imines

被引：6

作者：

Qian, CT ^{[1
]}

Huang, TS ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Organomet Chem Lab, Shanghai 200032, Peoples R China

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 1997年 / 548卷 / 02期

关键词：

organolanthanide reagent; regioselective addition; diastereoselective addition; alkyl lithium; allyl magnesium; N-alkyl alpha; beta-unsaturated imine; N-chiral alkyl alpha;

D O I：

10.1016/S0022-328X(97)00460-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Organolanthanum reagents[RLaCl2] generated in situ from LaCl3 and alkyl lithium or allyl magnesium could undergo a highly regioselective 1,2-addition to N-alkyl alpha,beta-unsaturated imines, which provided a new and useful approach to synthesize allyl amines with good yields and high regioselectivity. Furthermore, for N-chiral alkyl alpha,beta-unsaturated imine, in the case of n-butyl lithium, the diastereoselectivity achieved highly 90%. (C) 1997 Elsevier Science S.A.

引用

页码：143 / 147

页数：5

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