Comparative painting of mammalian chromosomes

被引:90
作者
Wienberg, J
Stanyon, R
机构
[1] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England
[2] Univ Munich, Inst Anthropol & Human Genet, D-8000 Munich, Germany
[3] Univ Genoa, Dipartimento Sci Antropol, I-16126 Genoa, Italy
基金
英国医学研究理事会;
关键词
D O I
10.1016/S0959-437X(97)80041-X
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Comparative chromosome painting has shown that synteny has been conserved for large segments of the genome in various placental mammals. Advances such as spectral karyotyping and multicolour 'bar coding' lend speed and precision to comparative molecular cytogenetics. Reciprocal chromosome painting and hybridisations with probes such as yeast artificial chromosomes, cosmids, and fibre fluorescence in situ hybridisation allow subchromosomal assignments of chromosome regions and can identify breakpoints of rearranged chromosomes. Advances in molecular cytogenetics can now be used to test the hypothesis that chromosome rearrangement breakpoints in human pathology and in evolution are correlated. (C) Current Biology Ltd ISSN 0959-437X.
引用
收藏
页码:784 / 791
页数:8
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