Aminoglycoside-induced reversible tubular dysfunction

被引：29

作者：

Alexandridis, G ^{[1
]}

Liberopoulos, E ^{[1
]}

Elisaf, M ^{[1
]}

机构：

[1] Univ Ioannina, Dept Internal Med, Sch Med, GR-45110 Ioannina, Greece

来源：

PHARMACOLOGY | 2003年 / 67卷 / 03期

关键词：

aminoglycosides; tubular damage; fanconi syndrome; hypokalemia hypomagnesemia; metabolic alkalosis; hypouricemia; GENTAMICIN THERAPY; POTASSIUM-DEPLETION; FRACTIONAL EXCRETION; FANCONI SYNDROME; MG2+ UPTAKE; HYPOMAGNESEMIA; NEPHROTOXICITY; MAGNESIUM; CELLS;

D O I：

10.1159/000067797

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nonoliguric renal insufficiency is a well-known nephrotoxic consequence of aminoglycosides, although reversible tubular damage in the absence of any change in the renal function has been occasionally found. Reported herein are 2 representative cases of a reversible tubular damage due to prolonged aminoglycoside administration: a patient with a Fanconi-like syndrome of proximal tubular dysfunction and a patient with a syndrome of hypokalemic metabolic alkalosis associated with hypomagnesemia. Copyright (C) 2003 S. Karger AG, Basel.

引用

页码：118 / 120

页数：3

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