In vitro activities of Citrus medica L. cv. diamante (diamante citron) relevant to treatment of diabetes and Alzheimer's disease

被引：86

作者：

Conforti, Filomena ^{[1
]}

Statti, Giancarlo Antonio ^{[1
]}

Tundis, Rosa ^{[1
]}

Loizzo, Monica Rosa ^{[1
]}

Menichini, Francesco ^{[1
]}

机构：

[1] Univ Calabria, Dept Pharmaceut Sci, I-87036 Arcavacata Di Rende, CS, Italy

来源：

PHYTOTHERAPY RESEARCH | 2007年 / 21卷 / 05期

关键词：

Citrus medica L. cv. Diamante; Rutaccae; antioxidant and hypoglycaemic activities; Alzheimer's disease;

D O I：

10.1002/ptr.2077

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The present study showed for the first time the in vitro properties (antioxidant, hypoglycaemic and anticholinesterase) of Citrus medica L. cv. Diamante which belongs to the Rutaceae family. The n-hexane extract of Diamante citron peel is characterized by the presence of monoterpones and sesquiterpenes. The most abundant constituents were two monoterpenes limonene and gamma-terpinene. The extract showed significant antioxidant activity that was carried out using different assays (DPPH lest, beta-carotene bleaching test and bovine brain peroxidation assay). Oxidative damage, caused by the action of free radicals, may initiate and promote the progression of a number of chronic diseases, including diabetes and Alzheimer's disease. Diamante citron peel extract showed hypoglycaemic activity and an anticholinesterase effect. Copyright (c) 2007 John Wiley & Sons, Ltd.

引用

页码：427 / 433

页数：7

共 48 条

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