Effects of estrogen and the selective estrogen receptor modulator raloxifene on markers of inflammation in postmenopausal women

被引：34

作者：

Blum, A

Schenke, WH

Hathaway, L

Mincemoyer, R

Csako, G

Waclawiw, MA

Cannon, RO

机构：

[1] NHLBI, Cardiol Branch, Bethesda, MD 20892 USA

[2] NHLBI, Off Biostat Res, Bethesda, MD 20892 USA

[3] NIH, Ctr Clin, Dept Clin Pathol, Bethesda, MD 20892 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2000年 / 86卷 / 08期

关键词：

D O I：

10.1016/S0002-9149(00)01116-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We measured soluble markers of inflammation in 23 healthy postmenopausal women after conjugated equine estrogens (CEE) 0.25 mg, raloxifene 60 mg, or placebo, each for 1 month, in a randomized, double-blind, 3-period trial. GEE, but not raloxifene, increased levels of C-reactive protein and matrix metalloproteinase-9 relative to placebo values; however, CEE reduced levels of cell adhesion molecules to a greater degree than raloxifene.

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页码：892 / +

页数：5

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