Multidrug transporter activity in lymphocytes

被引：33

作者：

Elliott, JI ^{[1
]}

Raguz, S ^{[1
]}

Higgins, CF ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, MRC Clin Sci Ctr, Membrane Transport Biol Grp, London W12 0NN, England

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2004年 / 143卷 / 07期

关键词：

lymphocytes; multidrug transporters; P-glycoprotein;

D O I：

10.1038/sj.bjp.0705940

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

I Multidrug transporters play a dual role in haematopoietic cells, mediating the efflux of xenobiotics and regulating cell migration. 2 For several reasons including the lack of specific antibodies, reports of multidrug transporter distribution on lymphocytes conflict. Murine B cells have been reported to completely lack transporter activity. 3 Through analysis of parental and 'knockout' mice we show that, contrary to previous studies, murine B and T lymphocytes possess at least three active multidrug transporters and also a hitherto unrecognised drug-specific import activity. 4 Surprisingly, the drug specificity of P-glycoprotein appears cell type dependent. The data indicate that a range of developmentally regulated, multidrug transporters can impose a barrier to treatment of immune disorders.

引用

页码：899 / 907

页数：9

共 42 条

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