The naturally acquired immunity in severe malaria and its implication for a PfEMP-1 based vaccine

被引：16

作者：

Chen, Qijun

机构：

[1] Karolinska Inst, Swedish Inst Infect Dis Control, Dept Parasitol Mycol & Environm Microbiol, S-17182 Solna, Sweden

[2] Karolinska Inst, Dept Microbiol Tumour & Cell Biol, S-17182 Solna, Sweden

[3] Jilin Univ, Inst Zoonosis, Minist Educ, Key Lab Zoonosis, Changchun 130062, Peoples R China

来源：

MICROBES AND INFECTION | 2007年 / 9卷 / 06期

关键词：

malaria; immunity; antigen; PfEMP1;

D O I：

10.1016/j.micinf.2007.02.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Malaria vaccine development has so far been largely focused on antigens involved in parasite invasion pathways rather than on antigens associated with severe disease and naturally acquired immunity. Individuals repeatedly exposed to Plasmodium falciparum will eventually become immune to severe disease. Parasite-derived antigens expressed on the infected red blood cell (iRBC) surface are the main targets of protective immunity and can be explored as a rational alternative in development of an anti-malaria vaccine. (C) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：777 / 783

页数：7

共 50 条

[1] Age-related buildup of humoral immunity against epitopes for rosette formation and agglutination in African areas of malaria endemicity [J].

Barragan, A ;

Kremsner, PG ;

Weiss, W ;

Wahlgren, M ;

Carlson, J .

INFECTION AND IMMUNITY, 1998, 66 (10) :4783-4787

[2] Blood group a antigen is a coreceptor in Plasmodium falciparum resetting [J].

Barragan, A ;

Kremsner, PG ;

Wahlgren, M ;

Carlson, J .

INFECTION AND IMMUNITY, 2000, 68 (05) :2971-2975

[3] Immunization of Aotus monkeys with a functional domain of the Plasmodium falciparum variant antigen induces protection against a lethal parasite line [J].

Baruch, DI ;

Gamain, B ;

Barnwell, JW ;

Sullivan, JS ;

Stowers, A ;

Galland, GG ;

Miller, LH ;

Collins, WE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (06) :3860-3865

[4] Invasion by P-falciparum merozoites suggests a hierarchy of molecular interactions [J].

Baum, Jake ;

Maier, Alexander G. ;

Good, Robert T. ;

Simpson, Ken M. ;

Cowman, Alan F. .

PLOS PATHOGENS, 2005, 1 (04) :299-309

[5] Antibody recognition of Plasmodium falciparum erythrocyte surface antigens in Kenya:: Evidence for rare and prevalent variants [J].

Bull, PC ;

Lowe, BS ;

Kortok, M ;

Marsh, K .

INFECTION AND IMMUNITY, 1999, 67 (02) :733-739

[6] Plasmodium falciparum infections are associated with agglutinating antibodies to parasite-infected erythrocyte surface antigens among healthy Kenyan children [J].

Bull, PC ;

Lowe, BS ;

Kaleli, N ;

Njuga, F ;

Kortok, M ;

Ross, A ;

Ndungu, F ;

Snow, RW ;

Marsh, K .

JOURNAL OF INFECTIOUS DISEASES, 2002, 185 (11) :1688-1691

[7] The role of antibodies to Plasmodium falciparum-infected-erythrocyte surface antigens in naturally acquired immunity to malaria [J].

Bull, PC ;

Marsh, K .

TRENDS IN MICROBIOLOGY, 2002, 10 (02) :55-58

[8] Plasmodium falciparum variant surface antigen expression patterns during malaria [J].

Bull, Peter C. ;

Berriman, Matthew ;

Kyes, Sue ;

Quail, Michael A. ;

Hall, Neil ;

Kortok, Moses M. ;

Marsh, Kevin ;

Newbold, Chris I. .

PLOS PATHOGENS, 2005, 1 (03) :202-213

[9] PLASMODIUM-FALCIPARUM ERYTHROCYTE ROSETTING IS MEDIATED BY PROMISCUOUS LECTIN-LIKE INTERACTIONS [J].

CARLSON, J ;

WAHLGREN, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (05) :1311-1317

[10] HUMAN CEREBRAL MALARIA - ASSOCIATION WITH ERYTHROCYTE ROSETTING AND LACK OF ANTI-ROSETTING ANTIBODIES [J].

CARLSON, J ;

HELMBY, H ;

HILL, AVS ;

BREWSTER, D ;

GREENWOOD, BM ;

WAHLGREN, M .

LANCET, 1990, 336 (8729) :1457-1460

← 1 2 3 4 5 →