Revaccination against hepatitis B virus of non-responding and low-responding infants immunised at birth. A parallel evaluation of rubella and tetanus vaccine

被引：26

作者：

Belloni, C

Tinelli, C

Orsolini, P

Pistorio, A

Avanzini, A

Moretta, A

Gulminetti, R

Bogliolo, O

Chirico, G

Rondini, G

机构：

[1] Policlin San Matteo, IRCCS, Div Neonatal Intens Care, I-27100 Pavia, Italy

[2] Policlin San Matteo, IRCCS, Biometr Unit, I-27100 Pavia, Italy

[3] Policlin San Matteo, IRCCS, Dept Infect Dis, I-27100 Pavia, Italy

[4] Policlin San Matteo, IRCCS, Res Lab Paediat Oncohematol Neonatal Immunol, I-27100 Pavia, Italy

[5] Univ Pavia, Dept Paediat, I-27100 Pavia, Italy

[6] Policlin San Matteo, IRCCS, Infect Dis Area, Expt Res Labs, I-27100 Pavia, Italy

来源：

VACCINE | 1998年 / 16卷 / 04期

关键词：

new-born; immunisation; HBV; rubella; tetanus; non-responsiveness;

D O I：

10.1016/S0264-410X(97)80917-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The aim of the present study was to identify the true extent of the non-responsiveness in infants born from HBsAg-negative mothers, vaccinated against Hepatitis B Virus (HBV) at birth. Sixty-four non- and low-responding infants, selected from an initial cohort of 2009, were given two additional doses of recombinant HBV vaccine between the tenth and twelfth month of age. A parallel evaluation was conducted on the response to anti-rubella and anti-tetanus vaccine. Only two infants remained non-responders, whereas 68% of the non-responders and 94% of the low responders after the primary vaccination scheduled developed antibody titres over 100 mIU ml(-1). No significant relationship between the specific antibody level against HBV and against rubella or tetanus 1 month after vaccination was observed. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：399 / 402

页数：4

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