Regulation of ubiquinone metabolism

被引:172
作者
Dallner, G [1 ]
Sindelar, PJ
机构
[1] Univ Stockholm, Dept Biochem, S-10691 Stockholm, Sweden
[2] Karolinska Inst, Dept Mol Med, Stockholm, Sweden
关键词
ubiquinone; mevalonate pathway; antioxidants; alpha-tocopherol; oxidative stress; peroxisome proliferators; free radicals;
D O I
10.1016/S0891-5849(00)00307-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Interest in ubiquinone (UQ) has increased during recent years, mainly because of its antioxidant function and its use as a dietary supplement. However, our knowledge of the biosynthesis, catabolism, and regulation of this lipid in mammalian tissues is quite limited. UQ exhibits a high rate of turnover in all tissues indicating that cells possess efficient metabolic pathways for handling this compound and controlling its tissue levels. Besides reviewing the generally accepted metabolic pathway, alternative synthetic mechanisms are described. The lack of data concerning catabolism and regulation of this compound is emphasized. Reasons for the rather limited uptake of dietary UQ are discussed and alternative mechanisms for its beneficial effects on organ function are suggested. Since appropriate tissue uptake of dietary UQ probably only occurs in deficient states, the definition of partial UQ deficiency and its consequences is urgently needed. The possibility of raising tissue UQ levels by drug treatment or natural metabolites is raised as a choice of preference for the future. (C) 2000 Elsevier Science Inc.
引用
收藏
页码:285 / 294
页数:10
相关论文
共 62 条
[1]   DISTRIBUTION AND REDOX STATE OF UBIQUINONES IN RAT AND HUMAN TISSUES [J].
ABERG, F ;
APPELKVIST, EL ;
DALLNER, G ;
ERNSTER, L .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1992, 295 (02) :230-234
[2]   EFFECTS OF CLOFIBRATE, PHTHALATES AND PROBUCOL ON UBIQUINONE LEVELS [J].
ABERG, F ;
ZHANG, YY ;
APPELKVIST, EL ;
DALLNER, G .
CHEMICO-BIOLOGICAL INTERACTIONS, 1994, 91 (01) :1-14
[3]   Increases in tissue levels of ubiquinone in association with peroxisome proliferation [J].
Aberg, F ;
Zhang, YY ;
Teclebrhan, H ;
Appelkvist, EL ;
Dallner, G .
CHEMICO-BIOLOGICAL INTERACTIONS, 1996, 99 (1-3) :205-218
[4]  
Åberg F, 1998, EUR J CLIN INVEST, V28, P235
[5]   EFFECT OF COLD EXPOSURE ON METABOLISM OF UBIQUINONE IN RAT [J].
AITHAL, HN ;
JOSHI, VC ;
RAMASARMA, T .
BIOCHIMICA ET BIOPHYSICA ACTA, 1968, 162 (01) :66-+
[6]   RATES OF CHOLESTEROL, UBIQUINONE, DOLICHOL AND DOLICHYL-P BIOSYNTHESIS IN RAT-BRAIN SLICES [J].
ANDERSSON, M ;
ELMBERGER, PG ;
EDLUND, C ;
KRISTENSSON, K ;
DALLNER, G .
FEBS LETTERS, 1990, 269 (01) :15-18
[7]   EXOGENOUS COQ(10) SUPPLEMENTATION PREVENTS PLASMA UBIQUINONE REDUCTION INDUCED BY HMG-COA REDUCTASE INHIBITORS [J].
BARGOSSI, AM ;
GROSSI, G ;
FIORELLA, PL ;
GADDI, A ;
DIGIULIO, R ;
BATTINO, M .
MOLECULAR ASPECTS OF MEDICINE, 1994, 15 :187-193
[8]   Coenzyme Q10 administration and its potential for treatment of neurodegenerative diseases [J].
Beal, MF .
BIOFACTORS, 1999, 9 (2-4) :261-266
[9]  
Beal MF, 1997, MOL ASPECTS MED, V18, pS169
[10]   Orphan nuclear receptors - new ligands and new possibilities [J].
Blumberg, B ;
Evans, RM .
GENES & DEVELOPMENT, 1998, 12 (20) :3149-3155