Control of SCAR activity in Dictyostelium discoideum

被引：12

作者：

Blagg, SL ^{[1
]}

Insall, RH ^{[1
]}

机构：

[1] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2004年 / 32卷

关键词：

cytoskeleton; Dictyostelium; motility; Nap1; PIR121; suppressor of cAMP receptor (SCAR);

D O I：

10.1042/BST0321113

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The WASP (Wiskott-Aldrich syndrome protein)/SCAR (suppressor of cAMP receptor) family of adaptor proteins regulate actin polymerization by coupling Rho-family GTPases to the activation of the Arp2/3 complex. SCAR exists within a complex of proteins, including Nap1 (Nck-associated protein 1), PIR121 (p53-inducible mRNA 121), Abi2 (Abl-interactor 2) and HSPC300. This complex was first reported to inhibit SCAR activity, but there is now some controversy over whether the complex is inhibitory or activatory. This complex is currently being studied in a wide range of different systems, and model organisms such as the amoeba Dictycistelium discoideum have been used to remove genetically SCAR complex members to ascertain their specific roles.

引用

页码：1113 / 1114

页数：2

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