A rigid C3v-symmetrical host for saccharide recognition:: 1,3,5-tris(2-hydroxyaryl)-2,4,6-trimethylbenzenes

被引：52

作者：

Abe, H ^{[1
]}

Aoyagi, Y ^{[1
]}

Inouye, M ^{[1
]}

机构：

[1] Toyama Med & Pharmaceut Univ, Fac Pharmaceut Sci, Toyama 9300194, Japan

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 01期

关键词：

D O I：

10.1021/ol047907c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A rigid C-3v-symmetrical host molecule, syn-1,3,5-tris(2-hydroxy-5-pentylphenyl)-2,4,6-trimethylbenzene, was readily obtained via Suzuki coupling and thermal atropisomerization. The host molecule effectively associated with various saccharides by multipoint hydrogen bonds, whereas its anti-atropisomer and analogue lacking in methyl groups showed much weaker association with saccharides. Thermodynamic analyses suggested that the difference of the association strength was caused by entropic factors.

引用

页码：59 / 61

页数：3

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