Effects of engrafted neural stem cells derived from GFP transgenic mice in Parkinson's diseases rats

被引：41

作者：

Wei, Peng ^{[1
]}

Liu, Jia ^{[1
]}

Zhou, Hao-Li ^{[1
]}

Han, Zhi-Tong ^{[1
]}

Wu, Qing-Ying ^{[1
]}

Pang, Jiang-Xia ^{[1
]}

Liu, Su ^{[1
]}

Wang, Ting-Hua ^{[1
]}

机构：

[1] Kunming Med Coll, Inst Neurosci, Kunming 650031, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2007年 / 419卷 / 01期

关键词：

green fluorescent protein transgenic mice; neural stem cells; Parkinson's disease; transplantation; rat;

D O I：

10.1016/j.neulet.2007.03.046

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

This study evaluated the therapeutic effect of neural stem cells (NSCs) transplanted into Parkinson's disease (PD) rats. NSCs were identified in vitro, then engrafted into the striatum of the PD rats. The rotational behavior was evaluated 1, 2, 4 and 6 weeks. A significant rotational behavior improvement was observed in PD rats subjected to cell transplantation. Transplanted NSCs not only express Nerve growth factor and Neurotrophin-3 in vitro, but also survive and partly differentiate into tyrosine hydroxylase (TH) positive cells in vivo. The results show that NSCs could be effective for PD treatment and the mechanisms might involve the neurotrophin expression and the neural differentiation. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

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收藏

页码：49 / 54

页数：6

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