Variability and regulation of O6-alkylguanine-DNA alkyltransferase

被引：162

作者：

Margison, GP ^{[1
]}

Povey, AC

Kaina, B

Koref, MFS

机构：

[1] Paterson Inst Canc Res, Canc Res UK Carcinogenesis Grp, Manchester M20 4BX, Lancs, England

[2] Univ Manchester, Ctr Environm & Occupat Hlth, Manchester M13 9PL, Lancs, England

[3] Johannes Gutenberg Univ Mainz, Inst Toxicol, Div Appl Toxicol, D-55131 Mainz, Germany

[4] Max Delbruck Ctr Mol Med, D-13092 Berlin, Germany

来源：

CARCINOGENESIS | 2003年 / 24卷 / 04期

关键词：

D O I：

10.1093/carcin/bgg005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

O-6-Alkylguanine-DNA alkyltransferase (ATase) confers resistance to many of the biological effects of certain classes of alkylating agents by repairing the DNA lesions responsible. The role of ATase in the mutagenic and toxic effects of the carcinogenic and antitumour alkylating agents are of interest in relation to the prevention and treatment of cancer in man. In this commentary we specifically focus on the variation in ATase levels and our current understanding of the factors involved in the regulation of ATase expression.

引用

页码：625 / 635

页数：11

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