Deconstructing gelsolin: identifying sites that mimic or alter binding to actin and phosphoinositides

被引：23

作者：

Janmey, PA ^{[1
]}

Stossel, TP ^{[1
]}

Allen, PG ^{[1
]}

机构：

[1] Brigham & Womens Hosp, Div Expt Med, Boston, MA 02115 USA

来源：

CHEMISTRY & BIOLOGY | 1998年 / 5卷 / 04期

关键词：

D O I：

10.1016/S1074-5521(98)90631-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gelsolin is involved in cytoskeletal remodeling as it can fragment and guide reassembly of actin networks. Recent advances in defining the structure of gelsolin identified functionally important sites. These structural insights could lead to the design of small molecule analogs to enhance, inhibit or mimic the functions of gelsolin.

引用

页码：R81 / R85

页数：5

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