Genetic analysis of the mechanisms controlling target selection: Complementary and combinatorial functions of netrins, semaphorins, and IgCAMs

被引:214
作者
Winberg, ML [1 ]
Mitchell, KJ [1 ]
Goodman, GS [1 ]
机构
[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Howard Hughes Med Inst, Berkeley, CA 94720 USA
关键词
D O I
10.1016/S0092-8674(00)81187-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The molecular mechanisms controlling the ability of motor axons to recognize their appropriate muscle targets were dissected using Drosophila genetics to add or subtract Netrin A, Netrin B, Semaphorin II, and Fasciclin II alone or in combination, Fas II and Sema II are expressed by all muscles where they promote (Fas II) or inhibit (Sema II) promiscuous synaptogenesis, NetB is expressed by a subset of muscles where it attracts some axons and repels others, However, growth cones in this system apparently do not rely solely on single molecular labels on individual targets, Rather, these growth cones assess the relative balance of attractive and repulsive forces and select their targets based on the combinatorial and simultaneous input of multiple cues.
引用
收藏
页码:581 / 591
页数:11
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