Singlet oxygen generation using iodinated squaraine and squaraine-rotaxane dyes

被引:58
作者
Arunkumar, Easwaran
Sudeep, Pallikkara K.
Kamat, Prashant V.
Noll, Bruce C.
Smith, Bradley D. [1 ]
机构
[1] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA
[2] Univ Notre Dame, Radiat Lab, Notre Dame, IN 46556 USA
关键词
D O I
10.1039/b616224j
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The goal of this study was to assess the ability of squaraine-rotaxanes to generate singlet oxygen for potential application in photodynamic therapy (PDT). Specifically, we compare the aggregation and photophysical properties of an iodinated squaraine dye and an iodinated squaraine-rotaxane. Even under strongly aggregating conditions, the absorption spectra of both remain relatively sharp. An X-ray crystal structure of the iodinated squaraine dye shows that it adopts perpendicular, end-to-face orientations in the solid state. Singlet oxygen generation efficiency was measured by trapping with 1,3-diphenylisobenzofuran. The triplet state of the rotaxane was characterized using laser. ash photolysis. The results of this study suggest that heavily halogenated squaraine-rotaxanes have potential as singlet oxygen photosensitizers for PDT.
引用
收藏
页码:677 / 683
页数:7
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