3-{2-[2-(2-Fluorobenzylidene)hydrazinyl]-1,3-thiazol-4-yl}-2H-chromen-2-one

被引:9
作者
Arshad, Afsheen [2 ]
Osman, Hasnah [2 ]
Lam, Chan Kit [3 ]
Quah, Ching Kheng [1 ]
Fun, Hoong-Kun [1 ]
机构
[1] Univ Sains Malaysia, Sch Phys, Xray Crystallog Unit, George Town 11800, Malaysia
[2] Univ Sains Malaysia, Sch Chem Sci, George Town 11800, Malaysia
[3] Univ Sains Malaysia, Sch Pharmaceut Sci, George Town 11800, Malaysia
来源
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2010年 / 66卷
关键词
ANTITUBERCULOSIS ACTIVITY; ANTIMICROBIAL ACTIVITY; COUMARIN; DERIVATIVES; INHIBITORS;
D O I
10.1107/S1600536810018647
中图分类号
O7 [晶体学];
学科分类号
070301 [无机化学];
摘要
In the title compound, C(19)H(12)FN(3)O(2)S, the chromene ring system and the thiazole ring are approximately planar [maximum deviations of 0.023 (3) angstrom and 0.004 (2) angstrom, respectively]. The chromene ring system is inclined at angles of 4.78 (10) and 26.51 (10)degrees with respect to the thiazole and benzene rings, respectively, while the thiazole ring makes a dihedral angle of 23.07 (12)degrees with the benzene ring. The molecular structure is stabilized by an intramolecular CH center dot center dot center dot O hydrogen bond, which generates an S(6) ring motif. The crystal packing is consolidated by intermolecular NH center dot center dot center dot O hydrogen bonds, which link the molecules into chains parallel to [ 100], and by C-H center dot center dot center dot pi and pi-pi [centroid-centroid distance = 3.4954 (15) angstrom] stacking interactions.
引用
收藏
页码:O1446 / U1734
页数:11
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