The influence of solvent choice, acid activation and surfactant addition on the hydrolytic kinetic resolution (HKR) of terminal epoxides

被引：11

作者：

Aerts, S

Buekenhoudt, A

Weyten, H

Vankelecom, IFJ

Jacobs, PA

机构：

[1] Vlaamse Instelling Technol Onderzoek, B-2400 Mol, Belgium

[2] Fac Bioengn Sci, B-3001 Heverlee, Belgium

来源：

TETRAHEDRON-ASYMMETRY | 2005年 / 16卷 / 03期

关键词：

D O I：

10.1016/j.tetasy.2004.11.024

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The recently developed hydrolytic kinetic resolution (HKR) of epoxides catalysed by the Co-Jacobsen catalyst, is one of the most useful methods to obtain enantiomerically pure epoxides and/or diols. Several parameters can significantly influence the homogeneous reaction. Several factors including the used solvent, the activation of the catalyst and the use of surfactants, are investigated. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：657 / 660

页数：4

共 5 条

[1] Practical access to highly enantioenriched C-3 building blocks via hydrolytic kinetic resolution [J].