Control of serial microfluidic droplet size gradient by step-wise ramping of flow rates

被引：20

作者：

Collins, John

Lee, Abraham Phillip ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Mech & Aerosp Engn, Irvine, CA 92717 USA

[2] Univ Calif Irvine, Dept Biomed Engn, Irvine, CA 92717 USA

来源：

MICROFLUIDICS AND NANOFLUIDICS | 2007年 / 3卷 / 01期

关键词：

microfluidic droplets; droplet sensing; high speed imaging; droplet generation frequency; microdroplet array;

D O I：

10.1007/s10404-006-0093-8

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

This paper describes a method to control and detect droplet size gradient by step-wise flow rate ramping of water-in-oil droplets in a microfluidic device. The droplets are generated in a cross channel device with two oil inlets and a water inlet. The droplet images are captured and analyzed in a time sequence in order to quantify the droplet generation frequency. It is demonstrated that by controlling the ramping of the oil flow rates it is possible to manipulate the ramping of droplet sizes. Increasing or decreasing of droplet sizes is achieved for a step-wise triangular ramping profile of the oil flow rate. The dynamic behavior of droplets due to the step-wise flow pulses is investigated. Uniform linear size ramping of water-in-oil droplets from 73 to 83 pm in diameter is generated with an oil flow ramping range from 1 to 11 mu L/min in a minimum of five steps while water flow rate is held constant at 2 mu L/min.

引用

页码：19 / 25

页数：7

共 31 条

[1] Formation of dispersions using "flow focusing" in microchannels [J].