Impact of Body Mass Index on Immunogenicity of Pandemic H1N1 Vaccine in Children and Adults

被引：40

作者：

Callahan, S. Todd ^{[1
,2
]}

Wolff, Mark ^{[3
]}

Hill, Heather R. ^{[3
]}

Edwards, Kathryn M. ^{[2
]}

机构：

[1] Vanderbilt Univ, Sch Med, Dept Pediat, Div Adolescent & Young Adult Hlth, Nashville, TN 37212 USA

[2] Vanderbilt Univ, Sch Med, Dept Pediat, Vanderbilt Vaccine Res Program, Nashville, TN 37212 USA

[3] EMMES Corp, Rockville, MD USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2014年 / 210卷 / 08期

关键词：

body mass index; influenza vaccine; immune response; obesity; OBESITY; INFLUENZA; RISK;

D O I：

10.1093/infdis/jiu245

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Obesity emerged as a risk factor for morbidity and mortality related to 2009 pandemic influenza A (H1N1) infection. However, few studies examine the immune responses to H1N1 vaccine among children and adults of various body mass indices (BMI). Pooling data from 3 trials of unadjuvanted split-virus H1N1 A/California/07/2009 influenza vaccines, we analyzed serologic responses of participants stratified by BMI grouping. A single vaccine dose produced higher hemagglutination inhibition antibody titers at day 21 in obese compared to nonobese adults, but there were no significant differences in responses to H1N1 vaccine among children or adults of various BMI following 2 doses.

引用

页码：1270 / 1274

页数：5

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