Interfering with inflammation: a new strategy to block breast cancer self-renewal and progression?

被引：21

作者：

Cabodi, Sara ^{[1
]}

Taverna, Daniela ^{[1
]}

机构：

[1] Univ Turin, Dept Oncol Sci, Ctr Mol Biotechnol, I-10126 Turin, Italy

来源：

BREAST CANCER RESEARCH | 2010年 / 12卷 / 02期

关键词：

STEM-CELLS;

D O I：

10.1186/bcr2563

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Two recent studies show that epigenetics and inflammation play a relevant role in the regulation of transformation and cancer cell self-renewal in breast tumours, opening up the possibility that cancer progression can be controlled by interfering with inflammation cascades. Struhl's group showed that transient activation of the Src oncoprotein induces transformation and self-renewal of immortal cells via an epigenetic switch involving NF-kappa B, Lin28, Let-7 microRNA and IL-6. Concomitantly, Wicha's laboratory developed a strategy to selectively target cancer stem cells, retarding tumour growth and reducing metastasis by blocking the IL-8 receptor CXCR1 using either an inhibitor, repertaxin or a specific blocking antibody.

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页数：2

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