High-level triclosan resistance in Pseudomonas aeruginosa is solely a result of efflux

被引：111

作者：

Chuanchuen, R ^{[1
]}

Karkhoff-Schweizer, RR ^{[1
]}

Schweizer, HP ^{[1
]}

机构：

[1] Colorado State Univ, Dept Microbiol Immunol & Pathol, Coll Vet Med & Biomed Sci, Ft Collins, CO 80523 USA

来源：

AMERICAN JOURNAL OF INFECTION CONTROL | 2003年 / 31卷 / 02期

关键词：

D O I：

10.1067/mic.2003.11

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background: Pseudomonas aeruginosa is intrinsically resistant to high levels of triclosan. Methods: Using the agar incorporation method and defined mutant strains, the contribution of multidrug efflux pumps to high-level (> 1000 mug/mL) triclosan resistance in P aeruginosa was assessed. Results: The results showed that the ability of P aeruginosa to survive in the presence of triclosan concentrations in excess of 1000 mug/mL is solely attributable to the expression of efflux pumps.

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页码：124 / 127

页数：4

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