Synthesis of novel dendrimeric systems containing NLO ligands

被引:17
作者
Brouwer, AJ [1 ]
Liskamp, RMJ [1 ]
机构
[1] Univ Utrecht, Inst Pharmaceut Sci, Dept Med Chem, NL-3508 TB Utrecht, Netherlands
关键词
dendrimers; amides; amino acids; synthesis design;
D O I
10.1002/ejoc.200400609
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The convergent synthesis of novel dendrimeric systems containing NLO-ligands is described. The poor solubility properties of dendrimers of type A containing NLO-ligands enticed us into developing novel dendrimers of type B leading to the convergent synthesis of third generation NLO-containing dendrimer 15 containing branches of unequal length. Furthermore, a strategy was developed for connection of dendrons leading to dendrimer-to-dendrimer systems of type C. For this a dendrimer was required of which selectively one branch could be deprotected i.e. dendrimer 22. To the deprotected branch a next dendrimer moiety was attached leading to 23, also containing a deprotectable branch, which was used for attachment of another dendrimer moiety, leading to dendrimer-to-dendrimer system 24. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005).
引用
收藏
页码:487 / 495
页数:9
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