Genome-wide analysis of the replication program in mammals

被引:45
作者
Farkash-Amar, Shlomit [1 ]
Simon, Itamar [1 ]
机构
[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Inst Med Research Israel Canada, Dept Microbiol & Mol Genet, IL-91010 Jerusalem, Israel
基金
以色列科学基金会;
关键词
time of replication; genomics; transcription; epigenetic; genomic stability; Microarrays; RIBOSOMAL-RNA GENES; DNA-REPLICATION; S-PHASE; SACCHAROMYCES-CEREVISIAE; CHROMOSOME-REPLICATION; HIGH-RESOLUTION; TEMPORAL-ORDER; FISSION YEAST; FORK MOVEMENT; TIME ZONES;
D O I
10.1007/s10577-009-9091-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Microarray technology has facilitated the research of eukaryotic DNA replication on a genome-wide scale. Recent studies have shed light on the association between time of replication and chromosome structure, on the organization principles of the replication program, and on the correlation between replication timing and transcription. In this review, we summarize various genomic measurement approaches and the biological insights achieved through applying them in the study of the mammalian replication program.
引用
收藏
页码:115 / 125
页数:11
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