Stem Cells and the Niche: A Dynamic Duo

被引：282

作者：

Voog, Justin ^{[1
,2
]}

Jones, D. Leanne ^{[1
,3
]}

机构：

[1] Univ Calif San Diego, Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA

[2] Univ Calif San Diego, Dept Biomed Sci, La Jolla, CA 92037 USA

[3] Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92037 USA

来源：

CELL STEM CELL | 2010年 / 6卷 / 02期

关键词：

SKELETAL-MUSCLE FIBERS; HEMATOPOIETIC STEM; SELF-RENEWAL; BONE-MARROW; DROSOPHILA OVARY; HAIR FOLLICLE; PROGENITOR CELLS; IN-VIVO; GERM-LINE; SMALL-INTESTINE;

D O I：

10.1016/j.stem.2010.01.011

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Stem cell niches are dynamic microenvironments that balance stem cell activity to maintain tissue homeostasis and repair throughout the lifetime of an organism. The development of strategies to monitor and perturb niche components has provided insight into the responsive nature of the niche and offers a framework to uncover how disruption of normal stem cell niche function may contribute to aging and disease onset and progression. Additional work in the identification of genetic factors that regulate the formation, activity, and size of stem cell niches will facilitate incorporation of the niche into stem cell-based therapies and regenerative medicine.

引用

页码：103 / 115

页数：13

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